化學(xué)配方數(shù)據(jù)庫(kù)
| 配方類型： |
COSMETICS AND DRUGS |
| 配方說明： |
Compression Coated Tablet (Multi-Layer Tablet) |
| 配方組成： |
Magnesium Stearate/1.01 g
Prepare a granulation of a, dry and screen through a #25=mesh
screen. Add lubricant b.
Lower Layer: (Slowest dissolution
10% starch/17.00 g
a: mannitol/1000.00 g
Magnesium Stearate/1.53 g
10% Gelatin/18.50 g
Solution/(185 ml)
b: Stearic Acid/5.09 g
Magnesium Stearate/1.02 g
Paste/(170 ml)
a: Lactose/1000.00 g
a: Mannitol/1000.00 g
2% "Methocel"/5.32 g
Solution/(266 ml)
b: Stearic Acid/2.54 g
b: Ste |
| 配制方法： |
Blend components of a, dry and screen through a #40-mesh screen. Add lubricant b.
Preparation of Tablets Machine: Stokes #566 Speed: 600 tablets/min Punches: 7/16-inch diam flatface beveled edge Pressure: 1.5-10 tons hardness: 5.5 kg Die fill: Upper layer: 0/187 inch Middle layer: 0.093 inch Lower layer: 0.093 inch Total: 0.373 inch Tablet Characteristics: Thickness: Upper layer: 0.065 inch Middle layer: 0.042 inch Lower layer: 0.040 inch Total: 0.147 inch Weight: 200 mg: 200 mg Middle layer: 140 mg Lower layer: 122 mg Total: 462 mg Disintegration time: Upper layer: 2 min Middle layer: 9 min Lower layer: 5.5 min Total: 9 min |
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